HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(3-Bromopropoxy)-4-fluorobenzene → Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(3-Bromopropoxy)-4-fluorobenzene | HCID 260004 | — |
| Edukt | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| Produkt | Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate | HCID 68501103 | — |
Reaktionsschritte
Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.758 g of 1-(3-bromopropoxy)-4-fluorobenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.13 (1:2 EtOAc-heptane); Rt=5.12.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07842688B2 |
| Quelldatensatz | uspto-grants-2010_11 |
| ORD ID | ord-608a5ef83ea44fd2978c81811e5fad92 |
| Quellennotiz | uspto-grants-2010_11 |