5-Bromopyrimidine-2-carboxylic acid → 5-bromo-N,N-dimethylpyrimidine-2-carboxamide
Reaktionsgleichung
[CH3:1][N:2]([CH3:12])[C:3]([C:5]1C=[CH:9][C:8]([Br:11])=[CH:7][N:6]=1)=[O:4].BrC1C=[N:16]C(C(O)=O)=NC=1>>[CH3:12][N:2]([CH3:1])[C:3]([C:5]1[N:6]=[CH:7][C:8]([Br:11])=[CH:9][N:16]=1)=[O:4]Komponenten
3
Versuchsvorschrift
The title compound was prepared in a similar manner as described for Intermediate 161a, from 5-bromopyrimidine-2-carboxylic acid (1.03 g, 5.074 mmol) to give a yellow oil (308 mg, 26% yield). 1H NMR (400 MHz, CDCl3) δ 8.50 (s, 2 H) 3.17 (s, 3 H) 3.00 (s, 3 H); LCMS for C7H8BrN3O m/z 230.00 and 232.00 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-dcc375404c884b378aea8c2afc619e58
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07842713B2
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