1-Methyl-3-aminopyrazole → 2-Hydroxymethyl-4-isopropoxy-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

HRID 1177210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1177210
C(O[C:6]([C:8]1[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:11]2[CH2:12][CH:13]([CH2:15][OH:16])[O:14][C:10]=2[CH:9]=1)=[O:7])(C)(C)C.[NH2:23][C:24]1[CH:28]=[CH:27][N:26]([CH3:29])[N:25]=1>>[CH3:29][N:26]1[CH:27]=[CH:28][C:24]([NH:23][C:6]([C:8]2[CH:18]=[C:17]([O:19][CH:20]([CH3:21])[CH3:22])[C:11]3[CH2:12][CH:13]([CH2:15][OH:16])[O:14][C:10]=3[CH:9]=2)=[O:7])=[N:25]1

Komponenten

3

Edukt 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 595601892-Hydroxymethyl-4-isopropoxy-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester

Produkt 1

HCID 595598442-Hydroxymethyl-4-isopropoxy-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide

Versuchsvorschrift

The title compound was prepared in a similar manner as described for Example 200, from 2-hydroxymethyl-4-isopropoxy-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester (215a) and 3-amino-1-methyl-pyrazole. 1H NMR (400 MHz, CDCl3) δ 8.34 (s, 1 H) 7.26-7.35 (m, 1 H) 6.95-7.05 (m, 1 H) 6.76-6.86 (m, 2 H) 4.93-5.08 (m, 1 H) 4.59-4.71 (m, 1 H) 3.84-3.91 (m, 1 H) 3.83 (s, 3 H) 3.22 (dd, J=16.42, 9.60 Hz, 1 H) 2.89-3.02 (m, 1 H) 1.98 (t, J=6.44 Hz, 1 H) 1.35 (d, J=6.06 Hz, 6 H); LCMS for C17H21N3O4 m/z 332.20 (M+H+).

Quellen und Nachweise

ORD-Eintrag
ord-686cdeaaa3f24036a30f96caad24aea5
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842713B2

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