Hydrochloric Acid → HCID 66953488, Verbindung

HRID 1178151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1178151
Cl.C(OC(=O)[NH:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:27])[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[Cl:26])[CH2:14][CH2:13]1)=[O:11])(C)(C)C>O1CCOCC1>[ClH:25].[NH2:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:27])[C:19]2[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=2[Cl:26])[CH2:14][CH2:13]1)=[O:11]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59559606{2-[4-(2,5-Dichloro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 66953488HCID 66953488, VerbindungAusbeute 78,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

Saturated HCl in 1,4-dioxane (1.0 mL) was added to a stirred solution of {2-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (280 mg, 0.67 mmol) in 1,4-dioxane (1.0 mL) at ambient temperature. The mixture was stirred at room temperature for 15 minutes then concentrated. The resulting solid was washed with diethyl ether to afford 2-amino-1-[4-(2,5-dichloro-benzoyl)-piperazin-1-yl]-ethanone hydrochloride as a solid in 78.9% yield. LC-MS purity: 94.019%

Aufarbeitung

  1. concentrationthen concentrated
  2. washThe resulting solid was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-616c294025684ca7a72a3bb8aac8c077
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07842696B2

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