HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1178564Erstellt: 26. Oktober 2026
Hydrochloric Acid → Methyl 2-chloro-3-[4-(2-hydroxyethyl)phenyl]propanoate
https://huagongshe.com/reaction/1178564
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Methyl Acrylate | HCID 7294 | — |
| Edukt | 4-Aminophenethyl alcohol | HCID 66904 | — |
| Edukt | Sodium Nitrite | HCID 23668193 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | Methyl 2-chloro-3-[4-(2-hydroxyethyl)phenyl]propanoate | HCID 86600802 | — |
Reaktionsschritte
2-(4-Aminophenyl)ethanol (11 g, 81 mmol) and 32 ml conc HCl was dissolved in acetone and cooled to 0° C. Sodium nitrite (5.6 g, 81 mmol) in 20 ml water was added dropwise. The temperature was kept under 0° C. After one hour, methyl acrylate (70 g, 808 mmol) and CuI (1.6 g, 8 mmol) were added (<0° C.). The reaction mixture was stirred at room temperature overnight.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07276539B2 |
|---|
| Quelldatensatz | uspto-grants-2007_10 |
|---|
| ORD ID | ord-1c9e5fe183944f61a4850dedfa5753dd |
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| Quellennotiz | uspto-grants-2007_10 |
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