Hydrochloric Acid → 2-(2-Amino-4-pyridyl)-1-(4-methoxyphenyl)ethanone

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2N-hydrochloric acid (30 mL) was added to 1-(4-methoxyphenyl)-2-(2-tert-butoxycarbonylamino-4-pyridyl)ethanone (6.1 g, 18 mmol) and the mixture was stirred at 100° C. for 2 hours. The reaction mixture was cooled to room temperature and, thereafter, 8N-aqueous sodium hydroxide (10 mL) was added. The resulting crude crystals were filtered and washed with water. The crude crystals were recrystallized from tetrahydrofuran-hexane to obtain 4.0 g of the title compound (16 mmol, yield 92%).

Herkunft & Nachweise