Methanol → 4-(2-Thienyl)butanoic acid methyl ester

HRID 1178616

Reaktionsgleichung

Reaktionsgleichung von HRID 1178616
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].S(=O)(=O)(O)O.[CH3:17]O>>[CH3:17][O:10][C:9](=[O:11])[CH2:8][CH2:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 783864-(2-Thienyl)Butyric Acid

Produkt 1

HCID 1407664-(2-Thienyl)butanoic acid methyl ester

Versuchsvorschrift

A mixture of 4-(2-thienyl)butyric acid (4.25 g, 25.0 mmol) and 3 mL of concentrated sulfuric acid in 25 mL of methanol is heated at reflux for 2 hours. The reaction mixture is cooled to room temperature and partitioned between ethyl acetate and saturated aqueous sodium carbonate solution. The organic layer is separated and passed through a short pad of silica gel. The filtrate is concentrated and purified by flash column chromatography eluting with 1:5 ethyl acetate:hexane to provide 4.02 g of 4-thiophen-2-yl-butyric acid methyl ester as a yellow oil, 1H NMR (DMSO-d6) δ 1.85 (quintet, J=7 Hz, 2H), 2.35 (t, J=7 Hz, 2H), 2.81 (t, J=7 Hz, 2H), 3.59 (s, 3H), 6.84 (m, 1 H), 6.95 (m, 1 H), 7.32 (dd, J=5, 1 Hz, 1H); MS 185.0 (M+H)+

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux for 2 hours
  3. custompartitioned between ethyl acetate and saturated aqueous sodium carbonate solution
  4. customThe organic layer is separated
  5. concentrationThe filtrate is concentrated
  6. custompurified by flash column chromatography
  7. washeluting with 1:5 ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-e7b935dd302b40d2b1111f08492c7f14
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07276519B2

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