1-(Cyclopropylmethyl)piperazine → 4-Cyclopropylmethyl-piperazine-1-Carboxylic acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

HRID 1179969Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1179969
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]2=[O:20])=[CH:7][CH:6]=1)=[O:3].[CH:21]1([CH2:24][N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)[CH2:23][CH2:22]1>>[CH3:18][C:14]1([CH3:19])[CH2:15][C:16](=[O:17])[N:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:28]3[CH2:29][CH2:30][N:25]([CH2:24][CH:21]4[CH2:23][CH2:22]4)[CH2:26][CH2:27]3)=[O:3])=[CH:6][CH:7]=2)[C:12](=[O:20])[CH2:13]1

Komponenten

3

Edukt 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 220478954-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate

Produkt 1

HCID 574558464-Cyclopropylmethyl-piperazine-1-Carboxylic acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

Versuchsvorschrift

The title compound was prepared from 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, preparative HPLC (Method C) (45%, off-white crystals). HPLC-MS m/z=400.3 (M+1), Rt: 1.83 min.

Quellen und Nachweise

ORD-Eintrag
ord-cf755149c18c413988c5b00294a7f926
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279470B2

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