1-((4-Methoxyphenyl)methyl)piperazine → 4-(4-Methoxy-benzyl)-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

HRID 1180008

Reaktionsgleichung

Reaktionsgleichung von HRID 1180008
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:5][CH:4]=1.Cl[C:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26](=[O:34])[NH:27][CH2:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:22][CH:21]=1)=[O:18]>ClCCl>[CH3:31][C:30]([CH3:33])([CH3:32])[CH2:29][CH2:28][NH:27][C:26]([C:23]1[CH:22]=[CH:21][C:20]([O:19][C:17]([N:11]2[CH2:12][CH2:13][N:8]([CH2:7][C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:15][CH:14]=3)[CH2:9][CH2:10]2)=[O:18])=[CH:25][CH:24]=1)=[O:34]

Komponenten

4

Edukt 2

HCID 2319051-((4-Methoxyphenyl)methyl)piperazineHCID 220478734-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate

Produkt 1

HCID 695177954-(4-Methoxy-benzyl)-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The title product was prepared from 1-(4-methoxy-benzyl)-piperazine (0.35 mmol) was dissolved in dichloromethane (5 ml). 4-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate (0.35 mmol) was added at room temperature. The reaction mixture was stirred for 16 h and evaporated to dryness and subjected to preparative HPLC (method C). (54%, colourless semicrystaline oil). HPLC-MS m/z=454.3 (M+1), Rt: 2.78 min.

Aufarbeitung

  1. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-2fdebb1b6d5c4eb48f6b48182cc2d98b
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07279470B2

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