1,2,4-Trifluoro-5-nitrobenzene → 4-Carbobenzyloxy-1-(4,5-difluoro-2-nitrophenyl)-piperazine-2-carboxylic acid

HRID 11811

Reaktionsgleichung

Reaktionsgleichung von HRID 11811
[C:1]([N:11]1[CH2:16][CH2:15][NH:14][CH:13]([C:17]([OH:19])=[O:18])[CH2:12]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[F:20][C:21]1[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[C:24](F)=[CH:23][C:22]=1[F:31]>>[C:1]([N:11]1[CH2:16][CH2:15][N:14]([C:24]2[CH:23]=[C:22]([F:31])[C:21]([F:20])=[CH:26][C:25]=2[N+:27]([O-:29])=[O:28])[CH:13]([C:17]([OH:19])=[O:18])[CH2:12]1)([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Komponenten

3

Edukt 2

HCID 750121,2,4-Trifluoro-5-nitrobenzeneHCID 50583624-((Benzyloxy)carbonyl)piperazine-2-carboxylic acid

Produkt 1

HCID 219766854-Carbobenzyloxy-1-(4,5-difluoro-2-nitrophenyl)-piperazine-2-carboxylic acidAusbeute 16,7 %

Versuchsvorschrift

By the same procedure described for example 2 method 2B, from 1.5 g of racemic 4-carbobenzyloxypiperazine-2-carboxylic acid and 1,2,4-trifluoro-5-nitro-benzene, there was obtained 0.4 g (16.7%) of title compound as an orange-red residue.

Quellen und Nachweise

ORD-Eintrag
ord-0b831c4cee1d41bab17511239d6c8b09
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098338B2

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