Acetic Acid → 4-Chloro-2,5-diamino-6-neopentyl-pyrimidine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Acetic Acid	HCID 176	—
Edukt	Sodium Acetate	HCID 517045	—
Edukt	Benzenediazonium, 4-chloro-, hexafluorophosphate(1-) (1:1)	HCID 2723983	—
Edukt	2-Amino-4-chloro-6-neopentylpyrimidine	HCID 22274982	—
Katalysator	Zinc	HCID 23994	—
Lösungsmittel	Water	HCID 962	—
Lösungsmittel	Water ethanol	HCID 19096565	—
Produkt	4-Chloro-2,5-diamino-6-neopentyl-pyrimidine	HCID 22274946	—

Reaktionsbedingungen

Temperatur	25 °C

Reaktionsschritte

A mixture of 2-amino-4-chloro-6-neopentylpyrimidine (1 mmol), sodium acetate (14 mmol), acetic acid (86 mmol), and 4-chlorobenzene-diazonium hexafluorophosphate (1.15 mmol) in water was stirred at 25° C. for 12 h. Extraction and evaporation gave a yellow solid which was treated with zinc dust (10 mmol) and acetic acid (5.54 mmol) in EtOH-H2O at 80° C. for 1 h. Extraction and chromatography gave 4-chloro-2,5-diamino-6-neopentyl-pyrimidine as a yellow solid. TLC: Rf=0.25, 50% EtOAc-hexane.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07285543B2
Quelldatensatz	uspto-grants-2007_10
ORD ID	ord-09ffa72cb21047dd815f426161ecb07a
Quellennotiz	uspto-grants-2007_10