Ammonia → 1-(2-Benzyl-1,3-thiazol-4-yl)methanamine

HRID 1181397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1181397
[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13]Cl)[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15]>>[CH2:1]([C:8]1[S:9][CH:10]=[C:11]([CH2:13][NH2:15])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 30158742-Benzyl-4-chloromethylthiazole

Produkt 1

HCID 209828961-(2-Benzyl-1,3-thiazol-4-yl)methanamineAusbeute 50 %

Versuchsvorschrift

2-Benzyl-4-chloromethylthiazole [Pharmazie 1972, 27, 146] (223.7 g, 1 mol) was stirred with liquid ammonia (600 ml) in an autoclave for 24 hours. The ammonia was removed and the product was distilled in vacuo [bp (0.02 mmHg) 141-144° C.] to give the title compound (102 g, 50%).

Aufarbeitung

  1. customThe ammonia was removed
  2. distillationthe product was distilled in vacuo [bp (0.02 mmHg) 141-144° C.]

Quellen und Nachweise

ORD-Eintrag
ord-57c04ec346d14abe86301c57106f7f6a
Quelldatensatz
uspto-grants-2007_10
Patentnummer
US07285563B2

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