alpha-Chloro-o-xylene → 5-methyl-7-(2-methylbenzyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	alpha-Chloro-o-xylene	HCID 11093	—
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	5-methyl-2-(1-naphthylmethyl)-3-(4-pyridinyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione	HCID 136334113	—
Produkt	5-methyl-7-(2-methylbenzyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione	HCID 58980981	—

Reaktionsbedingungen

Temperatur	80 °C

Reaktionsschritte

1-(chloromethyl)-2-methylbenzene (0.045 ml) and potassium carbonate (0.6 g) were added to a solution of 5-methyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (2 ml). The mixture was heated at 80° C. for 18 hours then cooled to room temperature. Solids removed by filtration and the crude product was purified on preparative HPLC to give the title compound (0.057 g). Mass: 487.87 (M+H).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07285558B2
Quelldatensatz	uspto-grants-2007_10
ORD ID	ord-e049f699c79d419ba37b8ffd2f9eebcf
Quellennotiz	uspto-grants-2007_10