{(S)-1-tert-butoxymethyl-3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propyl}-carbamic acid benzyl ester → (S)-1-tert-butoxymethyl-3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propylamine
Reaktionsgleichung
C(OC(=O)[NH:10][C@H:11]([CH2:26][O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH2:12][CH2:13][N:14]1[CH2:17][CH:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:15]1)C1C=CC=CC=1>CO>[C:28]([O:27][CH2:26][C@@H:11]([NH2:10])[CH2:12][CH2:13][N:14]1[CH2:15][CH:16]([O:18][C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[CH2:17]1)([CH3:31])([CH3:29])[CH3:30]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of {(S)-1-tert-butoxymethyl-3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propyl}-carbamic acid benzyl ester (0.2 g, 0.45 mmol) in methanol containing 10% palladium on carbon (66 mg) is stirred under an atmosphere of hydrogen for 3 hours, then filtered through a celite™ filter The filtrate is evaporated and the residue taken up in ethyl acetate, washed with aqueous NaHCO3 solution and brine, dried over MgSO4 and evaporated to afford (S)-1-tert-butoxymethyl-3-[3-(4-fluoro-phenoxy)-azetidin-1-yl]-propylamine.