Pyridine → 2-isopropyl-2,3-dimethyl-N-(1-(furan-2-yl)ethyl)butanamide

HRID 1183155Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1183155
N1C=CC=CC=1.[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]([NH2:14])[CH3:13].[CH:15]([C:18]([CH3:25])([CH:22]([CH3:24])[CH3:23])[C:19](Cl)=[O:20])([CH3:17])[CH3:16]>O1CCCC1>[CH:15]([C:18]([CH3:25])([CH:22]([CH3:24])[CH3:23])[C:19]([NH:14][CH:12]([C:8]1[O:7][CH:11]=[CH:10][CH:9]=1)[CH3:13])=[O:20])([CH3:17])[CH3:16]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 90729alpha-Methyl-2-furanmethanamineHCID 30166072,3-Dimethyl-2-isopropylbutyryl chloride

Produkt 1

HCID 666453802-isopropyl-2,3-dimethyl-N-(1-(furan-2-yl)ethyl)butanamideAusbeute 45,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

In a 25 mL round bottom flask, fitted with magnetic stirrer, 15 mL of tetrahydrofuran, 2.1 mmol (1.5 eq.) of pyridine and 1.54 mmol (1.1 eq.) of 1-(furan-2-yl)ethanamine were added. 1.4 mmol of 2-isopropyl-2,3-dimethylbutanoyl chloride (prepared by hydrolysis of 2-isopropyl-N,2,3-trimethylbutanamide, WS-23 with NaNO2 in H2SO4 and subsequent acid chloride formation with SOCl2) were added and the mixture was stirred at room to temperature for 16 hours, overnight. The reaction mixture was extracted with MTBE and HCl (1N in water). The organic layer was washed with NaOH (1N in water) and brine, dried over MgSO4 and concentrated. The crude product was purified by column chromatography, obtaining 160 mg of a beige solid, mp 57-60° C.

Aufarbeitung

  1. customIn a 25 mL round bottom flask, fitted with magnetic stirrer
  2. extractionThe reaction mixture was extracted with MTBE and HCl (1N in water)
  3. washThe organic layer was washed with NaOH (1N in water) and brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe crude product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-d023fd8c1d194eafa164c71dc9abbdfe
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08664261B2

Notizen zur Reaktion

Wird geladen…