HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1183261Erstellt: 25. Oktober 2026
Water → 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
https://huagongshe.com/reaction/1183261
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Water | HCID 962 | — |
| Edukt | Lithium Hydroxide | HCID 3939 | — |
| Edukt | Tetrahydrofuran | HCID 8028 | — |
| Edukt | 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester | HCID 66577705 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 1-{4'-[4-(2-Benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid | HCID 51347417 | — |
Reaktionsschritte
To 1-{4′-[4-(2-benzyl-cyclohexylamino)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester (0.130 g, 0.24 mmol) in 2:1:1 THF:H2O:MeOH was added lithium hydroxide (0.050 g, 1.19 mmol), and the reaction was stirred at 70° C. for 2 hours. After acidic workup, the crude material was purified by preparative HPLC to give the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08664220B2 |
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| Quelldatensatz | uspto-grants-2014_03 |
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| ORD ID | ord-f9296dd3ffd14f94b40390b63bb380f9 |
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| Quellennotiz | uspto-grants-2014_03 |
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