3-[4'-(4-Formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid ethyl ester → 3-{4'-[4-(1-Hydroxy-prop-2-ynyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-propionic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:23][N:22]=[C:21]([CH3:24])[C:20]=3[CH:25]=[O:26])=[CH:15][CH:14]=2)=[CH:9][CH:8]=1)[CH3:2].[C:28]([Mg]Br)#[CH:29]>>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[O:23][N:22]=[C:21]([CH3:24])[C:20]=3[CH:25]([OH:26])[C:28]#[CH:29])=[CH:15][CH:14]=2)=[CH:11][CH:12]=1)[CH3:2]Komponenten
3
Versuchsvorschrift
Prepared according to the procedure described in Example 25, Step 1, using 3-[4′-(4-formyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-propionic acid ethyl ester and ethynylmagnesium bromide.
Aufarbeitung
- customPrepared