4-(N-Ethylaminocarbonyl)phenylboronic acid → 4-[5-(4-Ethylcarbamoyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 1184739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1184739
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20](Cl)[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:24]([NH:26][C:27]([C:29]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31][CH:30]=1)=[O:28])[CH3:25]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[O:23][C:17]3=[CH:18][N:19]=[C:20]([C:32]4[CH:33]=[CH:34][C:29]([C:27](=[O:28])[NH:26][CH2:24][CH3:25])=[CH:30][CH:31]=4)[CH:21]=[C:16]3[CH2:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 34113074-(N-Ethylaminocarbonyl)phenylboronic acidHCID 866748954-(5-Chloro-2,3-dihydrofuro[2,3-c]pyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 679902534-[5-(4-Ethylcarbamoyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Versuchsvorschrift

The title compound is prepared from 4-(5-chloro-2,3-dihydro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and 4-(N-ethylaminocarbonyl)phenylboronic acid following a procedure analogous to that described in Example 28. LC (method 10): tR=1.66 min; Mass spectrum (ESI+): m/z=452 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-cc44339bd4fb4ec383fd9f744a32f44b
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08669271B2

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