Hydrochloric Acid → Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

HRID 1185438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1185438
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[C:20]1(C)C=CC=C[CH:21]=1>C(O)C>[CH2:20]([O:18][C:17]([C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)[CH:16]=1)=[O:19])[CH3:21]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

Produkt 1

HCID 27000068Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 40 ml of a saturated solution of hydrochloric acid in ethanol 2 g of 2-Furan-2-yl-quinoline-4-carboxylic acid was added and the mixture was heated to reflux for 3 h. Then, after cooling to RT, 30 ml of toluene was added and the solvents were removed under reduced pressure. The obtained crude product was pure enough for the next reaction step. Yield: 2.5 g.

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 h
  3. customthe solvents were removed under reduced pressure
  4. customThe obtained crude product
  5. customwas pure enough for the next reaction step

Quellen und Nachweise

ORD-Eintrag
ord-d5671b8c2b414fc28a2b84e0a9f1bd62
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08669266B2

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