Sodium Hydroxide → 2-Amino-5-chloro-3-methoxybenzoic acid

HRID 1186093

Reaktionsgleichung

Reaktionsgleichung von HRID 1186093
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][C:9]([Cl:14])=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 58566618Methyl 2-amino-5-chloro-3-methoxybenzoate

Produkt 1

HCID 545958742-Amino-5-chloro-3-methoxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 2-amino-5-chloro-3-methoxybenzoate (770 mg, 3.57 mmol) was suspended in tetrahydrofuran (20 mL), 2M sodium hydroxide (5 mL) was added and the mixture was stirred at ambient temperature for 20 hours. The solution was concentrated in vacuo, then partitioned between ethyl acetate and 1M hydrochloric acid. The organic layer was washed with water, then brine, dried with sodium sulfate, decanted and concentrated in vacuo to yield 2-amino-5-chloro-3-methoxybenzoic acid.

Aufarbeitung

  1. concentrationThe solution was concentrated in vacuo
  2. custompartitioned between ethyl acetate and 1M hydrochloric acid
  3. washThe organic layer was washed with water
  4. dry with materialbrine, dried with sodium sulfate
  5. customdecanted
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1edf70473893420eb539e1c3e358e451
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673897B2

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