Potassium Carbonate → 2-(1-(2-Nitrophenyl)ethylamino)acetonitrile

HRID 1186107

Reaktionsgleichung

Reaktionsgleichung von HRID 1186107
[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])([O-:3])=[O:2].[C:12]([O-])([O-])=O.[K+].[K+].C[CH:19](Br)[C:20]#[N:21]>C(#N)C>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH:6]([NH:7][CH2:19][C:20]#[N:21])[CH3:12])([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 1405382-BromopropionitrileHCID 423893(2-Nitrophenyl)methanamine

Produkt 1

HCID 866252282-(1-(2-Nitrophenyl)ethylamino)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

2-Nitrobenzylamine (513 mg, 3.37 mmol) was added to an acetonitrile (40 mL) containing K2CO3 (932 mg, 6.74 mmol) and 2-bromopropanitrile (677 mg, 5.06 mmol) under a nitrogen atmosphere. The reaction mixture was heated to 65° C. for 14 hours. The product (18) was used without purification or concentration in the next step.

Aufarbeitung

  1. customThe product (18) was used without purification or concentration in the next step

Quellen und Nachweise

ORD-Eintrag
ord-7ce1f772d6a549948b571a9eecbe3223
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673898B2

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