Oxalic Acid → 5-Trifluoromethyl-quinazoline-2,4-diamine

HRID 1186457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1186457
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[C:3]([NH2:8])[CH:2]=1.[C:9](O)(=[O:13])[C:10](O)=[O:11]>Cl>[NH:7]1[C:10](=[O:11])[C:9](=[O:13])[NH:8][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][C:4]1=2

Komponenten

4

Edukt 2

HCID 971Oxalic AcidHCID 59183,4-Diaminopyridine

Produkt 1

HCID 107970835-Trifluoromethyl-quinazoline-2,4-diamineAusbeute 107,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Pyridine-3,4-diamine (2.00 g, 18.3 mmol) and oxalic acid (1.96 g, 20.2 mmol) were dissolved in an aqueous hydrochloric acid solution (2.00 M, 20.0 mL) and the mixture was stirred with heat at 100° C. for 24 hours. After the reaction mixture was cooled to room temperature, the precipitate was collected by filtration and dried under reduced pressure. Thus, pyrido[3,4-b]pyrazine-2,3(1H,4H)-dione (3.20 g, 74%) was obtained.

Aufarbeitung

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ba671b75e81a4b0da17c094fb65b3474
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673908B2

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