4-Aminotetrahydropyran → (2-Methanesulfonyl-ethyl)-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Aminotetrahydropyran	HCID 419223	—
Edukt	2-(Methylthio)-4-(tributylstannyl)pyrimidine	HCID 2763261	—
Edukt	(3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester	HCID 68226902	—
Produkt	(2-Methanesulfonyl-ethyl)-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine	HCID 66548082	—

Reaktionsschritte

(2-Methanesulfonyl-ethyl)-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 418.2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08673905B2
Quelldatensatz	uspto-grants-2014_03
ORD ID	ord-96ff4bb949454c92910817c59c4c7eb1
Quellennotiz	uspto-grants-2014_03