4-Aminotetrahydropyran → Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine

HRID 1186476

Reaktionsgleichung

Reaktionsgleichung von HRID 1186476
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10](Cl)[C:5]2=[N:4][CH:3]=1.C(OC([N:19]1[CH2:24][CH2:23][CH:22]([NH2:25])[CH2:21][CH2:20]1)=O)(C)(C)C.CS[C:28]1[N:33]=[C:32]([Sn](CCCC)(CCCC)CCCC)[CH:31]=[CH:30][N:29]=1.[NH2:47][CH:48]1[CH2:53][CH2:52][O:51][CH2:50][CH2:49]1>>[NH:19]1[CH2:20][CH2:21][CH:22]([NH:25][C:10]2[C:5]3[N:6]([C:2]([C:32]4[CH:31]=[CH:30][N:29]=[C:28]([NH:47][CH:48]5[CH2:53][CH2:52][O:51][CH2:50][CH2:49]5)[N:33]=4)=[CH:3][N:4]=3)[CH:7]=[CH:8][N:9]=2)[CH2:23][CH2:24]1

Komponenten

5

Edukt 4

HCID 4192234-AminotetrahydropyranHCID 12682914-Amino-1-Boc-piperidineHCID 27632612-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 100598493-Bromo-8-chloroimidazo[1,2-a]pyrazine

Produkt 1

HCID 66548258Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine

Versuchsvorschrift

Piperidin-4-yl-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine was prepared by a process analogous to that described in Example 12 starting from 3-bromo-8-chloro-imidazo[1,2-a]pyrazine (from Example 1 supra), 4-amino-piperidine-1-carboxylic acid tert-butyl ester, 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 395.4.

Quellen und Nachweise

ORD-Eintrag
ord-d81abd5f0c3a45808e959d085b5e0fee
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673905B2

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