HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methylamine → (2-Methanesulfonyl-ethyl)-[3-(2-methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methylamine | HCID 6329 | — |
| Edukt | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | HCID 2763261 | — |
| Edukt | (3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester | HCID 68226902 | — |
| Produkt | (2-Methanesulfonyl-ethyl)-[3-(2-methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine | HCID 66548442 | — |
Reaktionsschritte
(2-Methanesulfonyl-ethyl)-[3-(2-methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and methylamine. LC-MS: [M+H]+ 348.2.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08673905B2 |
| Quelldatensatz | uspto-grants-2014_03 |
| ORD ID | ord-a062fbe27a6b44a0ab275a283e2bfcf7 |
| Quellennotiz | uspto-grants-2014_03 |