tert-butyl N-(2-amino-2-phenylethyl)carbamate → HCID 68226914, Verbindung

HRID 1186502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1186502
CS([C:5]1[N:10]=[C:9]([C:11]2[N:15]3[CH:16]=[CH:17][N:18]=[C:19]([N:20]4[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]4)[C:14]3=[N:13][CH:12]=2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[C:27]([O:31][C:32](=[O:43])[NH:33][CH2:34][CH:35]([NH2:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:43])[NH:33][CH2:34][CH:35]([NH:42][C:5]1[N:10]=[C:9]([C:11]2[N:15]3[CH:16]=[CH:17][N:18]=[C:19]([N:20]4[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]4)[C:14]3=[N:13][CH:12]=2)[CH:8]=[CH:7][N:6]=1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)([CH3:30])([CH3:28])[CH3:29]

Komponenten

3

Edukt 2

HCID 2771847tert-butyl N-(2-amino-2-phenylethyl)carbamateHCID 68226486HCID 68226486, Verbindung

Produkt 1

HCID 68226914HCID 68226914, VerbindungAusbeute 26 %

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

The mixture of 3-(2-methanesulfonyl-pyrimidin-4-yl)-8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazine (from Example 46 supra) (120 mg, 0.32 mmol) and (2-amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester (from Example 51 supra) (305 mg, 1.29 mmol) was heated at 140° C. with stirring for 2 hours. The oil was purified by chromatography (silica gel, 10 g, 200-300 mesh, eluting with dichloromethane:methanol, 50:1 to 20:1) to afford crude (2-{4-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester (Yield 44 mg).

Aufarbeitung

  1. customThe oil was purified by chromatography (silica gel, 10 g, 200-300 mesh, eluting with dichloromethane:methanol, 50:1 to 20:1)

Quellen und Nachweise

ORD-Eintrag
ord-bb81807842ff46f9bf042aa001cbfead
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673905B2

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