4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamide → 4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(4-methoxy-phenyl)-benzenesulfonamide

HRID 1186665

Reaktionsgleichung

Reaktionsgleichung von HRID 1186665
[Cl:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:13])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2OC)(=[O:23])=[O:22])=[CH:17][CH:16]=1.ClC1C=C(S(N=C2C3C(=CC=CC=3)[C:47](=[O:54])C(Cl)=C2)(=O)=O)SC=1Cl>>[Cl:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:13])[C:3]=1[NH:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([NH:24][C:25]2[CH:26]=[CH:27][C:28]([O:54][CH3:47])=[CH:29][CH:30]=2)(=[O:23])=[O:22])=[CH:17][CH:16]=1

Komponenten

3

Edukt 2

HCID 446086564-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamideHCID 673306684,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide

Produkt 1

HCID 673315194-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(4-methoxy-phenyl)-benzenesulfonamide

Versuchsvorschrift

5.2.41 N,N-dimethyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide (13f) was prepared according to the procedure for 13d except using 4,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophenesulfonamide (12c) and 3-mercapto-N,N-dimethylpropanamide( ) which afforded the title compound 16.1 mg (48%) as a white solid, m.p.: ° C.

Quellen und Nachweise

ORD-Eintrag
ord-1c63a5e24c11489288c51f1d6ae99654
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673910B2

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