2-{[1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yl]sulfanyl}acetic acid → 2-(4-(4,5-Dichlorothiophene-2-sulfonamido)-1-hydroxynaphthalen-2-ylthio)acetic acid

HRID 1186674

Reaktionsgleichung

Reaktionsgleichung von HRID 1186674
OC1C2C(=CC=CC=2)C(NS(C2SC=CC=2)(=O)=O)=CC=1[S:21][CH2:22][C:23]([OH:25])=[O:24].[Cl:26][C:27]1[CH:28]=[C:29]([S:33]([N:36]=[C:37]2[C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:40](=[O:47])[C:39](Cl)=[CH:38]2)(=[O:35])=[O:34])[S:30][C:31]=1[Cl:32]>>[Cl:26][C:27]1[CH:28]=[C:29]([S:33]([NH:36][C:37]2[C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[C:40]([OH:47])=[C:39]([S:21][CH2:22][C:23]([OH:25])=[O:24])[CH:38]=2)(=[O:35])=[O:34])[S:30][C:31]=1[Cl:32]

Komponenten

3

Edukt 2

HCID 15826052-{[1-Hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-yl]sulfanyl}acetic acidHCID 673306684,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamide

Produkt 1

HCID 446091472-(4-(4,5-Dichlorothiophene-2-sulfonamido)-1-hydroxynaphthalen-2-ylthio)acetic acid

Versuchsvorschrift

5.2.56 2-(4-(4,5-dichlorothiophene-2-sulfonamido)-1-hydroxynaphthalen-2-ylthio)acetic acid (14n) was prepared according to the procedure of procedure B for 10a except using 4,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophenesulfonamide (12c), which afforded the title compound 17.8 mg (39%) as a white solid, m.p.: ° C.

Quellen und Nachweise

ORD-Eintrag
ord-38f9fabba7604306a2035cddb7d05f9e
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673910B2

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