3-Bromo-2,5-dimethylbenzoic acid → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1187064Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1187064
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

Komponenten

3

Edukt 1

HCID 592382453-Bromo-2,5-dimethylbenzoic acid

Produkt 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0° C., then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

Aufarbeitung

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-45967cbc690843e1ac8c0cb2df08461b
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08673920B2

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