Methyl iodide → 4-bromo-1,6-dimethylpyridin-2(1H)-one

Reaktionsgleichung

[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[CH:3]=1.CI.[C:12]([O-])([O-])=O.[K+].[K+]>>[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:12])[C:4](=[O:9])[CH:3]=1

Komponenten

Edukt 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 231494724-Bromo-6-methylpyridin-2-ol

Produkt 1

HCID 667365044-bromo-1,6-dimethylpyridin-2(1H)-one

Versuchsvorschrift

4-bromo-1,6-dimethylpyridin-2(1H)-one was prepared by methylation of 4-bromo-6-methylpyridin-2(1H)-one with methyl iodide using K2CO3 following a procedure analogous to that described in Example 59 Step 1.

Quellen und Nachweise

ORD-Eintrag: ord-f3acabace36c4dd0814870a7ed645800
Quelldatensatz: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08673899B2

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