Piperazine → 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

HRID 1188296

Reaktionsgleichung

Reaktionsgleichung von HRID 1188296
CO[C:3]1([C:8]2[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=2)[C:5]([CH3:7])([CH3:6])[O:4]1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>ClCCl>[CH3:6][C:5]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([CH3:7])[C:3]([C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 201925252-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

Produkt 1

HCID 233257252-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).

Aufarbeitung

  1. customFurther, in a 500 mL four-neck flask provided with a stirrer, a condenser
  2. temperatureAfter cooling
  3. washan organic layer was washed three times with 70 mL of water
  4. dry with materialThe organic layer was dried with anhydrous sodium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-924c4bc3a53c456787de4b2d41573fe2
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674089B2

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