StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Dimethylformamide → ethyl 2-(3-cyano-2-cyclopentyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

HRID 1189538
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1189538
[CH:1]1([C:6]2[N:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:9]([CH3:17])=[C:8]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[S:25]([N:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)(=[O:27])=[O:26])[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.ClS([N:37]=[C:38]=O)(=O)=O.CN(C)C=O>C(#N)C>[C:38]([C:7]1[C:8]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[S:25]([N:28]2[CH2:29][CH2:30][CH2:31][CH2:32]2)(=[O:26])=[O:27])=[C:9]([CH3:17])[N:10]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:6]=1[CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)#[N:37]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 70918Chlorosulfonyl isocyanateHCID 53246982ethyl 2-(5-cyclopentyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

Produkt 1

HCID 53246146ethyl 2-(3-cyano-2-cyclopentyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342
Acetonitrile
Lösungsmittel

Versuchsvorschrift

To a solution of ethyl 2-(5-cyclopentyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (2.54 g, 5.54 mmol) in acetonitrile (28 mL) was added chlorosulfonyl isocyanate (0.818 ml, 9.42 mmol). The reaction was stirred at room temperature for 30 minutes, after which the starting pyrrole had still not been consumed. The reaction was then heated to 55° C. for 30 minutes after which the starting pyrrole was consumed (by LCMS analysis). To the reaction mixture at 55° C. was added N,N-dimethylformamide (0.729 ml, 9.42 mmol). The reaction was stirred at 55° C. for 30 minutes after which analysis of the reaction (by LCMS) indicated that the reaction to afford the desired product was complete. The reaction was quenched by the addition of water, and extracted with dichloromethane (3×50 mL), dried (sodium sulfate), filtered and concentrated to a deep maroon residue. Purification was achieved by silica gel chromatography (Luknova 240 g, 20 mL/min) using 1 to 7% of a 7:1 acetonitrile/methanol solution in dichloromethane over 70 minutes. The product ethyl 2-(3-cyano-2-cyclopentyl-5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate (747 mg, 1.55 mmol, 28% yield) was isolated as a white foam. 1H NMR (400 MHz, CDCl3) δ (ppm): 8.01 (d, 1H), 7.40 (dd, 1H), 7.30 (ddd, 1H), 6.99 (d, 1H), 4.59 (s, 2H), 4.30 (s, 2H), 4.27 (q, 2H), 3.32-3.36 (m, 4H), 2.96 (m, 1H), 1.84-2.09 (m, 13H, composite of multiple shifts), 1.63-1.71 (m, 2H).

Aufarbeitung

  1. customafter which the starting pyrrole had still not been consumed
  2. temperatureThe reaction was then heated to 55° C. for 30 minutes after which the starting pyrrole
  3. customwas consumed (by LCMS analysis)
  4. stirringThe reaction was stirred at 55° C. for 30 minutes
  5. customafter which analysis of the reaction (by LCMS)
  6. customindicated that the reaction

Quellen und Nachweise

ORD-Eintrag
ord-e1b71d084d954e3b8b054b8e0ba18cf8
Quelldatensatz
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08674115B2

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion