Nitric Acid → 2-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

HRID 1189676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189676
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].OS(O)(=O)=O>>[Cl:5][C:6]1[C:14]([CH3:15])=[C:13]([F:16])[C:12]([N+:1]([O-:4])=[O:2])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 108453152-Chloro-4-fluoro-3-methylbenzoic acid

Produkt 1

HCID 105138312-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

Versuchsvorschrift

Aq HNO3 (65%, 0.39 mL) is added at 0° C. to a mixture of 2-chloro-3-methyl-4-fluoro-benzoic acid (880 mg, 4.7 mmol) and 8 mL conc H2SO4 and it is stirred for 2 h without further cooling. The mixture is poured into ice water and the precipitate is collected by filtration and dried.

Aufarbeitung

  1. filtrationthe precipitate is collected by filtration
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-da14ae3dc166415aa27d3a794a378cf8
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

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