Methanol → Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

HRID 1189685Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1189685
S(Cl)(Cl)=O.[Cl:5][C:6]1[CH:14]=[C:13]([NH:15][CH3:16])[C:12]([N+:17]([O-:19])=[O:18])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9].[CH3:20]O>>[CH3:20][O:9][C:8](=[O:10])[C:7]1[CH:11]=[C:12]([N+:17]([O-:19])=[O:18])[C:13]([NH:15][CH3:16])=[CH:14][C:6]=1[Cl:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

Produkt 1

HCID 67957559Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

Versuchsvorschrift

Thionylchloride (3.87 g, 32 mmol) is added dropwise at rt to a mixture of 2-chloro-4-methylamino-5-nitro-benzoic acid (5.00 g, 22 mmol) and 45 mL MeOH and it is stirred at reflux overnight. The mixture is cooled to rt and the precipitate is collected by filtration and dried. Yield: 5.01 g. MS m/z: 245 [M+H]+.

Aufarbeitung

  1. temperatureat reflux overnight
  2. filtrationthe precipitate is collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-17cd38c7ba6c4b629211428c8b58e90a
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674113B2

Notizen zur Reaktion

Wird geladen…