Methanol → HCID 178480843, Verbindung

HRID 1189776

Reaktionsgleichung

Reaktionsgleichung von HRID 1189776
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[N:10]=[C:11]([N+:14]([O-])=O)[NH:12][CH:13]=2)[CH2:4][CH2:3]1.CO.C1COCC1.CO.[S:26]1[CH:30]=[C:29]([C:31]2[C:40]3[N:39]=[CH:38][CH:37]=[N:36][C:35]=3[C:34]([C:41](O)=[O:42])=[CH:33][CH:32]=2)[C:28]2[CH:44]=[CH:45][CH:46]=[CH:47][C:27]1=2>[Ni].C(Cl)Cl.CO>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[N:10]=[C:11]([NH:14][C:41]([C:34]3[C:35]4[N:36]=[CH:37][CH:38]=[N:39][C:40]=4[C:31]([C:29]4[C:28]5[CH:44]=[CH:45][CH:46]=[CH:47][C:27]=5[S:26][CH:30]=4)=[CH:32][CH:33]=3)=[O:42])[NH:12][CH:13]=2)[CH2:4][CH2:3]1

Komponenten

7

Edukt 4

HCID 887MethanolHCID 21899815MeOH tetrahydrofuranHCID 669146368-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acidHCID 178480844HCID 178480844, Verbindung

Produkt 1

HCID 178480843HCID 178480843, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 21226129Dichloromethane methanolLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 20 h at 65° C., using 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 8-benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid (Example 59) in Step 14.1. Title compound: ESI-MS: 484.0 [M+H]+; tR=3.36 min (System 1); TLC: Rf=0.10 (DCM/MeOH, 9:1).

Aufarbeitung

  1. customThe title compound was prepared in analogy to the procedures

Quellen und Nachweise

ORD-Eintrag
ord-e9bbc96e26c143199281bad6624bdfdc
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08674099B2

Verknüpfte Notizen

Wird geladen…