Trifluoroacetic acid → HCID 58495523, Verbindung
Reaktionsgleichung
[CH:1]1([CH2:4][NH:5][C:6]2[N:11]=[C:10]([C:12]3[CH:26]=[CH:25][C:15]([CH2:16][NH:17]C(OC(C)(C)C)=O)=[CH:14][CH:13]=3)[CH:9]=[CH:8][N:7]=2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH:1]1([CH2:4][NH:5][C:6]2[N:11]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH2:16][NH2:17])=[CH:25][CH:26]=3)[CH:9]=[CH:8][N:7]=2)[CH2:3][CH2:2]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Dissolve 4-[2-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-(tert-butoxycarbonyl)-benzylamine (195 mg, 0.55 mmol) in DCM (3 mL) and add trifluoroacetic acid (1.5 mL). Stir at room temperature for 3 h. Concentrate in vacuo and purify the crude mixture by SCX chromatography (5 g) to obtain the title compound (140 mg, 93%) suitable for use without additional purification. MS (ES+) m/z: 255 (M+H)+.