Thionyl Chloride → 1-Chloro-6-(trifluoromethyl)indane
Reaktionsgleichung
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2O)=[CH:5][CH:4]=1.S(Cl)([Cl:17])=O>>[Cl:17][CH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[C:3]([C:2]([F:14])([F:13])[F:1])[CH:11]=2)[CH2:7][CH2:8]1Komponenten
3
Versuchsvorschrift
6-(Trifluoromethyl)indan-1-ol (1.52 g, 7.5 mmol) was dissolved in thionyl chloride (15 mL). After being stirred at room temperature for 2 hrs, the solution was concentrated in vacuo to provide the title compound (1.5 g, 90%).
Aufarbeitung
- concentrationthe solution was concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-5b43fae121be4ee2983fffb600d666fa
- Quelldatensatz
- uspto-grants-2014_03
- Patentnummer
- US08680104B2
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