Methyl iodide → 3-(2-Methoxy-2-oxoethyl)-1,1-dimethyl-3-(5-phenethylfuran-2-carboxamido)-piperidinium iodide
Reaktionsgleichung
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([CH2:24][C:25]([O:27][CH3:28])=[O:26])([NH:8][C:9]([C:11]2[O:12][C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:15]=2)=[O:10])[CH2:3]1.[CH3:29][I:30]>>[I-:30].[CH3:28][O:27][C:25](=[O:26])[CH2:24][C:4]1([NH:8][C:9]([C:11]2[O:12][C:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:15]=2)=[O:10])[CH2:5][CH2:6][CH2:7][N+:2]([CH3:29])([CH3:1])[CH2:3]1Komponenten
3
Versuchsvorschrift
According to the method described in example 2a, methyl 2-(1-methyl-3-(5-phenethyl-furan-2-carboxamido)piperidin-3-yl)acetate was reacted with methyl iodide to give the title compound as a white solid (quantitative). MS ESI 399.2 [M]+, calcd for [C23H31N2O4]+ 399.21.
Quellen und Nachweise
- ORD-Eintrag
- ord-c58ce349d3254df795a4beab42c512cb
- Quelldatensatz
- uspto-grants-2014_03