HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
tert-Butanol → 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | tert-Butanol | HCID 6386 | — |
| Edukt | Ethyl Acrylate | HCID 8821 | — |
| Edukt | Potassium | HCID 5462222 | — |
| Edukt | 3-Azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 10932520 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Lösungsmittel | Tert-butanol tetrahydrofuran | HCID 66775918 | — |
| Produkt | 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester | HCID 86749790 | — |
Reaktionsschritte
A solution of 3-azido-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one [prepared as described by Watthey et al., J. Med. Chem., 28, p. 1511-15156 (1985)] in tetrahydrofuran/tert-butanol was cooled to 0° C. and treated with ethyl acrylate and 1N tert-butanol, potassium salt/tetrahydrofuran according to the procedure of Example 40 part (a) affording 3-azido-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-propanoic acid, ethyl ester as a syrup. TLC (ethyl ether:hexane, 1:1) Rf =0.45.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05723457 |
| Quelldatensatz | uspto-grants-1998_03 |
| ORD ID | ord-1a4951c4532f4cb2bdd53951628d0ded |
| Quellennotiz | uspto-grants-1998_03 |