Trifluoroacetic acid → (R)-Methyl 3-amino-2,3-dihydro-1H-indene-5-carboxylate

HRID 1193251Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193251
C(O)(C(F)(F)F)=O.C(OC([NH:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1)=O)(C)(C)C>ClCCl>[NH2:15][C@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59505324Methyl (R)-3-((tert-butoxycarbonyl)amino)-2,3-dihydro-1H-indene-5-carboxylate

Produkt 1

HCID 55278060(R)-Methyl 3-amino-2,3-dihydro-1H-indene-5-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

TFA (10 ml) was added dropwise at 0° C. to a solution of (R)-methyl 3-(tert-butoxycarbonyl-amino)-2,3-dihydro-1H-indene-5-carboxylate (2.3 g, 7.9 mmol, 1 eq) in dichloromethane (50 ml), and stirring was carried out for 1 h at RT. Then the solvent was reduced under reduced pressure. The crude product was used in the following stage without being purified and analyzed further.

Aufarbeitung

  1. customwithout being purified

Quellen und Nachweise

ORD-Eintrag
ord-2d1d2022ac6a44558d9643b512d68ce2
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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