Trifluoroacetic acid → Benzyl methyl(piperidin-4-yl)carbamate

HRID 1193373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193373
[CH2:1]([O:8][C:9]([N:11]([CH3:25])[CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][N:11]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57753905HCID 57753905, Verbindung

Produkt 1

HCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

tert-Butyl 4-((benzyloxycarbonyl)(methyl)amino)piperidine-1-carboxylate (0.3 g, 0.682 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (2.5 ml) was added at 0° C. and stirring was carried out for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

Quellen und Nachweise

ORD-Eintrag
ord-8e1110e4de924ff7a4f9d7cb88be3303
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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