tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate → 4-N-Boc-4-N-Methyl-aminopiperidine

HRID 1193389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193389
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:22])[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[CH3:22][N:14]([CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:18])[CH3:19]

Komponenten

3

Edukt 1

HCID 18476608tert-Butyl (1-benzylpiperidin-4-yl)methylcarbamate

Produkt 1

HCID 27568064-N-Boc-4-N-Methyl-aminopiperidineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

tert-Butyl 1-benzylpiperidin-4-yl(methyl)carbamate (1.0 g, 3.289 mmol, 1.0 eq.) was dissolved in MeOH (15 ml) and degassed with argon. Pd/C (300 mg) was then added and hydrogenation was carried out for 4 hours. After monitoring by TLC, the reaction mixture was filtered over Celite and the filtrate was concentrated under reduced pressure. The crude product was used in the next stage without being purified further. Yield: 85% (600 mg, 2.803 mmol)

Aufarbeitung

  1. customdegassed with argon
  2. additionPd/C (300 mg) was then added
  3. filtrationthe reaction mixture was filtered over Celite
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customwithout being purified further

Quellen und Nachweise

ORD-Eintrag
ord-7367616cf3984297a5c4518a2954ef88
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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