Methyl isothiocyanate → HCID 86663381, Verbindung

HRID 1193392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193392
[CH3:1][N:2]=[C:3]=[S:4].[CH3:5][N:6]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>ClCCl>[CH3:5][N:6]([CH:17]1[CH2:18][CH2:19][N:20]([C:3](=[S:4])[NH:2][CH3:1])[CH2:21][CH2:22]1)[C:7](=[O:16])[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 11167Methyl isothiocyanateHCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

Produkt 1

HCID 86663381HCID 86663381, VerbindungAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of methyl isothiocyanate (500 mg, 6.8493 mmol, 1 eq) in dichloromethane (4 ml) was added dropwise over a period of 5 min to a solution of benzyl methyl(piperidin-4-yl)carbamate (stage 3 AMN-52) (1.7 g, 6.8493 mmol, 1 eq). When the addition was complete, the reaction mixture was stirred for 20 hours at room temperature. Concentration under reduced pressure was then carried out and the crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane). Yield: 45% (1 g, 3.115 mmol)

Aufarbeitung

  1. additionWhen the addition
  2. concentrationConcentration under reduced pressure
  3. customthe crude product was purified by column chromatography (silica gel, 2% methanol in dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-6ac9c05858274756aebffa91cb4db4c4
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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