Trifluoroacetic acid → N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

HRID 1193394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193394
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1)C(=O)OC(C)(C)C>ClCCl>[CH3:8][NH:9][CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 66798554tert-Butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate

Produkt 1

HCID 62131647N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid (1 ml) was added at 0° C. to a solution of tert-butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate (241 mg, 0.82 mmol, 1 eq) in dichloromethane (5 ml), and the reaction mixture was stirred for 1 h at room temperature. Concentration under reduced pressure was then carried out. The crude product so obtained was used in the next stage without being purified further.

Aufarbeitung

  1. concentrationConcentration under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-291a5f2cf6774ef689cf7e3b58fdc86f
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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