Potassium Carbonate → HCID 66798808, Verbindung

HRID 1193396Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193396
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([O:9][CH3:10])[N:3]=1.[CH3:11][N:12]([CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[C:13](=[O:22])[O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:10][O:9][C:4]1[N:3]=[C:2]([N:26]2[CH2:25][CH2:24][CH:23]([N:12]([CH3:11])[C:13](=[O:22])[O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:28][CH2:27]2)[CH:7]=[C:6]([CH3:8])[N:5]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 134258364-Chloro-2-methoxy-6-methylpyrimidineHCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

Produkt 1

HCID 66798808HCID 66798808, VerbindungAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-2-methoxy-6-methylpyrimidine (300 mg, 1.8987 mmol, 1 eq), benzyl methyl(piperidin-4-yl)carbamate (stage 3 AMN-52) (470 mg, 1.8987 mmol, 1 eq) and K2CO3 (523 mg, 3.796 mmol, 2 eq) in acetone (10 ml) was refluxed for 16 h. When the reaction was complete according to TLC monitoring, filtration over Celite was carried out and the filtrate was concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 2% methanol/dichloromethane). The desired product was in the form of a light-yellow solid. Yield: 71% (500 mg, 1.3513 mmol)

Aufarbeitung

  1. temperaturewas refluxed for 16 h
  2. filtrationWhen the reaction was complete according to TLC monitoring, filtration over Celite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe crude product was purified by column chromatography (silica gel, 2% methanol/dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-c650793b5ff1464aa194293de14e18b8
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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