Trifluoroacetic acid → Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

HRID 1193414Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1193414
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[CH2:8]([O:15][C:16]([N:18]([CH2:32][CH3:33])[CH:19]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[CH2:32]([N:18]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:16](=[O:17])[O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:33]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 18677722Tert-butyl 4-(((benzyloxy)carbonyl)(ethyl)amino)piperidine-1-carboxylate

Produkt 1

HCID 66799319Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

TFA (2.5 ml) was added at 0° C. to a solution of tert-butyl 4-((benzyloxycarbonyl)(ethyl)-amino)piperidine-1-carboxylate (1.5 g, 414 mmol, 1.0 eq) in DCM (10 ml) and the mixture was stirred for 2 hours at RT. After monitoring by TLC, the reaction mixture was concentrated under reduced pressure and dried. The crude product was used in the next stage without being purified further.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

Quellen und Nachweise

ORD-Eintrag
ord-64797714bca04b9494c3d5d12c02f32f
Quelldatensatz
uspto-grants-2014_03
Patentnummer
US08680159B2

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