Ethyl Bromide → (4R,9aR)-6-Ethoxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

HRID 11936

Reaktionsgleichung

Reaktionsgleichung von HRID 11936
[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15](Br)=[CH:14][CH:13]=3)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:23]([O:27]C(N1C[C@@H](C)N2[C@H](CC3C2=NC(O)=CC=3)C1)=O)(C)(C)[CH3:24].[H-].[Na+].C(Br)C>>[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15]([O:27][CH2:23][CH3:24])=[CH:14][CH:13]=3)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

5

Edukt 4

HCID 6332Ethyl BromideHCID 24758Sodium hydrideHCID 86590113(4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl esterHCID 178418747HCID 178418747, Verbindung

Produkt 1

HCID 21044425(4R,9aR)-6-Ethoxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

Versuchsvorschrift

This compound was prepared in analogy to Example 22 intermediate b), from (4R,9aR)-6-hydroxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester, sodium hydride and ethyl bromide.

Quellen und Nachweise

ORD-Eintrag
ord-66a1909896b24caab495aec954787752
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098337B2

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