HCID 13304948, Verbindung → HCID 19989904, Verbindung
Reaktionsgleichung
[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)[C:8]=1[CH3:9])[CH3:2].[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[O:23][CH2:24][C:25]#[C:26][Mg]Br>>[CH2:1]([C:3]1[C:4]([O:15][CH3:16])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([C:13](=[O:14])[C:26]#[C:25][CH2:24][O:23][CH:18]3[CH2:19][CH2:20][CH2:21][CH2:22][O:17]3)[N:12]=2)[C:8]=1[CH3:9])[CH3:2]Komponenten
3
Versuchsvorschrift
6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-carboxaldehyde and 3-(tetrahydropyran-2-yloxy)-1-propynyl-magnesium bromide [J. Chem. Soc., 1950, 3646] were reacted by the method of Step A of Example 1 to obtain 1-(6-ethyl-7-methoxy-5-methylimidazol[1,2-a]pyrimidin-2-yl)-4-(tetrahydropyran-2-yloxy)-2-butyn-1-one.
Quellen und Nachweise
- ORD-Eintrag
- ord-be93dddb66ed4dd89aab7e7958f9bbea
- Quelldatensatz
- uspto-grants-1989_03
- Patentnummer
- US04810828