Sodium ethoxide → 2-ethoxy-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone
Reaktionsgleichung
Cl[C:2]1[N:3]([C:13]2[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:16]([Cl:23])=[CH:15][C:14]=2[F:24])[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[CH3:25][CH2:26][O-:27].[Na+]>C(O)C>[CH2:26]([O:27][C:2]1[N:3]([C:13]2[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:16]([Cl:23])=[CH:15][C:14]=2[F:24])[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1)[CH3:25]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and sodium ethylate in ethanol there is obtained 2-ethoxy-1-(4-chloro-2-fluoro -5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 101°-103° C.;