Hydrochloric Acid → 5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

HRID 1194017

Reaktionsgleichung

Reaktionsgleichung von HRID 1194017
O.[NH:2]1[C:10](=[O:11])[C:8](=[O:9])[C:6](=[O:7])[NH:5][C:3]1=[O:4].[CH3:12][N:13]1[CH:17]=[CH:16][CH:15]=[CH:14]1.Cl>C(O)C>[OH:9][C:8]1([C:14]2[N:13]([CH3:12])[CH:17]=[CH:16][CH:15]=2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[NH:2][C:10]1=[O:11]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 73041-MethylpyrroleHCID 167232,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate

Produkt 1

HCID 212712485-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrioneAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

Aufarbeitung

  1. temperaturethe mixture warmed for 5 minutes on a steam bath
  2. customthe reaction mixture was evaporated to dryness
  3. customthe residue triturated with water

Quellen und Nachweise

ORD-Eintrag
ord-a38e6d010aea463790b4a4bb1506e098
Quelldatensatz
uspto-grants-1989_03
Patentnummer
US04812471

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